The Lilywhites were beaten by Burnley at the weekend, 3-0, and Bristol City at home the week before.
They now have to avoid defeat in order to avoid a piece of unwanted history – six defeats in a row at Deepdale for the first time in the club’s history.
Ryan Lowe has hinted at making some changes to his side and he needs a win, with what should be a fully fit squad to choose from.
1. Ryan Lowe could make changes
Preston North End's Tom Cannon under pressure from Burnley's Josh Brownhill Photo: CameraSport - Rich Linley
2. GK: Freddie Woodman
Freddie Woodman has been one of the most consistent players for North End this season and has done nothing wrong to lose his place. Photo: CameraSport - Alex Dodd
3. CB: Jordan Storey
North End need to keep more clean sheets but unless Bambo Diaby comes in on the right side, there's no clear replacement for Storey, who in fairness has not been bad. Photo: CameraSport - Alex Dodd
4. CB: Bambo Diaby
North End will likely make changes for the game so this could be one. Liam Lindsay had a torrid time on Saturday and Diaby is generally well-liked by the PNE staff. Photo: CameraSport - Mick Walker