The Lilywhites were beaten by Burnley at the weekend, 3-0, and Bristol City at home the week before.
They now have to avoid defeat in order to avoid a piece of unwanted history – six defeats in a row at Deepdale for the first time in the club’s history.
Ryan Lowe has hinted at making some changes to his side and he needs a win, with what should be a fully fit squad to choose from.
5. CB: Andrew Hughes
A consistent performer on the left side of the defence. Greg Cunningham could also potentially come into the side but even if he does he could be down the middle with Hughes still on the left. Photo: CameraSport - Alex Dodd
6. RWB: Brad Potts
With North End potentially in need of some changes, the industry of Potts down the right could release Browne from the right and allow a different option. Photo: CameraSport - Rich Linley
7. CM: Ben Whiteman
PNE need to get control of a game and get a result against Luton and starting Ben Whiteman could help them in maintaining some possession and hopefully some more defensive stability. Photo: Martin Rickett
8. CM: Alan Browne
PNE have struggled to find consistency in the middle of midfield and it might be time to put the skipper back in there, with Brad Potts fit again. Photo: CameraSport - Rich Linley