PNE are looking to continue their unbeaten start to the new Championship campaign as they face newly-relegated Ipswich Town.
Meanwhile, the Tractor Boys have begun life back in the second-tier with back-to-back draws against Birmingham City and Southampton.
We’ve taken a look at the early team and injury news from both camps as North End bid to extend their unbeaten start to the season.
5. Brad Potts - Out
Potts missed the remaining two months of last season due to a hamstring injury. The midfielder felt an issue in the final two weeks of pre-season, with Heckingbottom admitting he didn’t want to take any chances on the 31-year-old. | Ben Roberts Photo/Getty Images Photo: Ben Roberts Photo/Getty Images
6. Will Keane - Out
Keane picked up a calf injury in the later stages of pre-season and missed the final two weeks of preparations. He continues to be absent for Heckingbottom. | CameraSport - Dave Howarth
7. Sammie Szmodics - Out
The former Blackburn man suffered arm and knee injuries during Sunday’s 1-1 draw against Southampton and is expected to be absent for the trip to Deepdale. | Getty Images
8. Robbie Brady - Out
Brady is another member of Heckingbottom’s side who will be sidelined against Ipswich as he continues his recovery from a calf issue sustained in pre-season. | CameraSport - Ian Cook