The Seasiders continue to be depleted by injuries and suspension, with Jordan Thorniley and Gary Madine the latest doubts.
But Appleton does have Marvin Ekpiteta and Dom Thompson back from suspension, while James Husband, Rhys Williams and Liam Bridcutt could all feature.
But how will the Seasiders line up? We take our best guess here...
. Blackpool's manager Michael Appleton looks on Photographer Andrew Kearns/CameraSport The EFL Sky Bet Championship - Sheffield United v Blackpool - Saturday 15th October 2022 - Bramall Lane - Sheffield World Copyright © 2022 CameraSport. All rights reserved. 43 Linden Ave. Countesthorpe. Leicester. England. LE8 5PG - Tel: +44 (0) 116 277 4147 - [email protected] - www.camerasport.com
Michael Appleton remains limited to what he can change to his injury-hit Blackpool side Photo: CameraSport - Andrew Kearns
. GK - Chris Maxwell
Despite the calls for Dan Grimshaw to return, I expect Maxi to keep the number one jersey. It will be an emotional game for him so he needs to ensure he keeps his head. Photo: CameraSport - Andrew Kearns
. RB - Callum Connolly
Connolly will be required to fill in at right-back once again, with Jordan Gabriel not expected back until the New Year. Photo: CameraSport - Dave Howarth
. CB - Marvin Ekpiteta
The skipper should come straight back into the side after serving his one-game ban. Big boost to have him back, especially for such a significant game. Photo: CameraSport - Dave Howarth
1. GK - Chris Maxwell
Despite the calls for Dan Grimshaw to return, I expect Maxi to keep the number one jersey. It will be an emotional game for him so he needs to ensure he keeps his head. Photo: CameraSport - Andrew Kearns
2. RB - Callum Connolly
Connolly will be required to fill in at right-back once again, with Jordan Gabriel not expected back until the New Year. Photo: CameraSport - Dave Howarth
3. CB - Marvin Ekpiteta
The skipper should come straight back into the side after serving his one-game ban. Big boost to have him back, especially for such a significant game. Photo: CameraSport - Dave Howarth
4. CB - Jordan Thorniley
Fingers crossed he passes his fitness test and is fit enough to start, because he's an important player for Pool. Otherwise Rhys Williams or James Husband could deputise. Photo: CameraSport - Dave Howarth