The Seasiders continue to be depleted by injuries and suspension, with Jordan Thorniley and Gary Madine the latest doubts.
But Appleton does have Marvin Ekpiteta and Dom Thompson back from suspension, while James Husband, Rhys Williams and Liam Bridcutt could all feature.
But how will the Seasiders line up? We take our best guess here...
5. LB - Dom Thompson
James Husband is unlikely to be match fit to start, while Luke Garbutt also looked rusty on his first appearance of the season in midweek. So Thompson could return following his suspension. Photo: CameraSport - Andrew Kearns
6. CDM - Liam Bridcutt
Michael Appleton suggested Bridcutt is fit enough to start after being given a breather in midweek. His discipline and organisation could prove key. Photo: CameraSport - Dave Howarth
7. CM - Kenny Dougall
Should be full of confidence after scoring twice in his last two games. Likely to see him play in a more advanced position again. Photo: CameraSport - Dave Howarth
8. CM - Charlie Patino
The midfielder's quality on the ball will be crucial in the midfield battle. It will be fascinating to see how he gets on against the dangerous Ben Whiteman. Photo: CameraSport - Dave Howarth