The Seasiders continue to be depleted by injuries and suspension, with Jordan Thorniley and Gary Madine the latest doubts.
But Appleton does have Marvin Ekpiteta and Dom Thompson back from suspension, while James Husband, Rhys Williams and Liam Bridcutt could all feature.
But how will the Seasiders line up? We take our best guess here...
9. RW - Theo Corbeanu
The Seasiders will need an improved Corbeanu at both ends of the field, especially with his tracking back and work off the ball. Photo: CameraSport - Dave Howarth
10. LW - Jerry Yates
Pool will need the striker firing on all cylinders again if they're going to get a result. His defensive work will be crucial as well though. Photo: CameraSport - Dave Howarth
11. ST - Gary Madine
I expect Madine to be fit, even if it means playing through the pain barrier once again. His aerial threat is likely to prove vital in both boxes. Photo: CameraSport - Dave Howarth