Paul Pilson-Campbell was last seen in the Marian Square area of Bootle area on Friday, January 7.
The 16-year-old is described as a white male, 5ft 9in tall, of slim build with short, light brown hair.
He was last seen wearing black pants, a jacket and a head/face covering.
Paul has links to Netherton, Bootle and Preston in Lancashire, police said.
Anyone who has seen Paul or knows of his whereabouts was urged to direct message @MerseyPolice on Twitter or by calling 101.
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