Preston North End make the lengthy trip down to the South Coast to face Southampton at St Mary's in the Sky Bet Championship.
The Lilywhites arrive in Hampshire on the back of a seven game unbeaten run, following their goalless draw with Hull City at the weekend. PNE couldn't narrow the gap on the play-offs, but they didn't lose any major ground either.
Southampton, meanwhile, got themselves back among the winning trail after back-to-back defeats against Hull City and Millwall. The Saints won 4-3 against Birmingham City, courtesy of Joe Aribo's strike in stoppage time.
Southampton are fourth and are still in contention for an automatic promotion spot, despite the good form of Ipswich Town and Leeds United. The two sides met at Deepdale back in October and it was Southampton who were perhaps the most fortunate.
Preston led through Milutin Osmajic and Brad Potts who scored in a three-minute salvo, after Kyle Walker-Peters' well placed opener. But, a Potts own goal in the sixth minute of additional time denied PNE the victory.
Neither side's injury list is too long, but there are players who will miss out. Southampton have invested heavily in their squad, but they're to be without one of their most expensive acquisitions, - who has been reduced to just two substitute outings this term. Here is the latest injury and team news ahead of kick-off on Wednesday night.
5. Ross Stewart - out
Joined Southampton when dealing with an Achilles tendon injury. He made two substitute appearances for the Saints in November but has been sidelined since. His season is all but over, having played less than a half of football. | Getty Images
6. Ross Stewart - out (continued)
Russell Martin said: "I think we need to be really honest about Ross and realistic - we probably won't see him again this season. Although it's short term pain for us, long term we need Ross to have a full pre-season. To then risk him for maybe three or four weeks of this season seems a little bit crazy, but it depends on the situation we're in. I'm not going to come out here and lie pretending he might be fit, so I think if we say he's not going to be here this season and then if you do see him at some point, it's a huge bonus." | Getty Images
7. Juan Larios - out
He's been rehabbing in his native Spain - having suffered a 'severe' hamstring injury in September. He hasn't played for more than a year and it is likely that he won't play in the 2023/24 campaign. | Getty Images
8. Juan Larios - out (continued)
Russell Martin said on February 20: "He is here, he is back in the building and it has been lovely to have him back for the last few weeks. He has got a lot of work to do to get there. It is nice to have him and we really like Juan, we've been so disappointed for him. " | Getty Images