It is the first meeting between the sides at Deepdale since August 2013 and the first in the league since 2010.
Here we are look at some past meetings which put a smile on the faces of North End supporters.
5. Paddy power at Deepdale
Mark Patterson scored his first goal in a PNE shirt as Preston beat Blackpool 1-0 at Deepdale in September 1988 Photo: LEP staff
6. Super Mickey Conroy.....
PNE beat Blackpool 1-0 at Deepdale in November 1994, Mike Conroy settling the FA Cup first round tie with a header Photo: LEP staff
7. Goals on legs......
Gary Bennett, described as 'goals on leg's by PNE manager Gary Peters, came off the bench to score twice in a 3-0 win over Blackpool in December 1996 Photo: IAN ROBINSON
8. He stoops to conquer
Gary Bennett heads his second and PNE third's goal against Blackpool at Deepdale in December 1996 Photo: IAN ROBINSON