It is the first meeting between the sides at Deepdale since August 2013 and the first in the league since 2010.
Here we are look at some past meetings which put a smile on the faces of North End supporters.
. PNE v Blackpool memories
Who put the ball in the Blackpool net? Super Tommy Clarke did.......Tom Clarke turns to celebrate after scoring PNE's winner against Blackpool in August 2013. Photo: Kevin McGuinness
. FA Cup delight for North End
Preston North End beat Blackpool 2-1 at Deepdale in the second round of the FA Cup in December 1982 Photo: Staff
. Rare joy in re-election season
PNE beat Blackpool 2-1 at Deepdale in the first round, first leg of the League Cup. They then won the away leg 3-1 at Bloomfield Road Photo: LEP Staff
. Win on the plastic
Early in the 1986/87 promotion season, PNE beat Blackpool 2-1 in the League Cup, drawing the second leg 0-0 Photo: LEP Staff
. Christmas victory
Gary Swann and Gary Brazil scored as PNE came from a goal down to win 2-1 against Blackpool at Deepdale on Boxing Day, 1987 Photo: LEP staff
. Paddy power at Deepdale
Mark Patterson scored his first goal in a PNE shirt as Preston beat Blackpool 1-0 at Deepdale in September 1988 Photo: LEP staff
13. Celebration time
Michael Appleton and David Eyres celebrate PNE's third goal against Blackpool in December 1999 Photo: KEVIN McGUINNESS
14. Making himself a hero...
Tom Clarke heads home against Blackpool in August 2013 Photo: Kevin McGuinness
15. Late, late joy!
Tom Clarke celebrates with Paul Huntington after scoring PNE's winner against Blackpool in August 2013 Photo: Kevin McGuinness