The last time the two sides met, the Chairboys dumped Preston out of the FA Cup with a 4-1 hammering, and their league meeting at Deepdale back in December finished 2-2.
Speaking ahead of the game, Preston boss Alex Neil revealed he's already working on transfer plans for the summer, and claimed: "The recruitment side is going to be huge for us this summer. We are all aware we have got a massive rebuilding job which half started in January and is going to hopefully continue in the summer.
“We have a large number of loans at the moment and we will see what we can do with some of them. Equally, we have some other players out of contract in the summer.
“I would imagine, whether the loan lads stay or not, that it will be the biggest overhaul of the squad we have probably had in the summer.”
Here are today's biggest transfer stories and the latest team news involving Preston North End and the rest of the Championship, as the build-up to the upcoming weekend's action begins.
9. Preston target tipped for exit
Ex-Aston Villa ace Gabby Agbonlahor has hinted that Villa striker Keinan Davis could leave the club this summer, as he "just wants to play football". Preston North End and Derby County are both thought to be interested in the player. (Football Insider) Photo: Pool
10. Keane among favourites for Celtic job
Ex-Nottingham Forest man Roy Keane has emerged as the second-favourite for the Celtic job, behind John Kennedy and ahead of Eddie Howe. He's not managed a club since he left Ipswich Town back in 2011. (SkyBet) Photo: Lewis Storey