North End go in search of their third win in just six dayt after success against Middlesbrough and Swansea City since Saturday.
The Royals on the other hand have lost and drawn their last two, but are on home soil for the clash.
PNE do not have the best of records against the hosts going into the game, winning just one of their last nine games against Reading, but have a chance to go into the play-offs with a win.
Here’s how we think Ryan Lowe will line up…
9. LWB: Robbie Brady
He had one of his best games in a North End shirt against Swansea and should keep his place against the Royals. Photo: CameraSport - Alex Dodd
10. ST: Emil Riis
As North End's biggest goal threat, the Dane is most likely to continue up front, having scored against Middlesbrough less than a week ago too. Photo: CameraSport - Alex Dodd
11. ST: Sean Maguire
Ched Evans is unlikely to be able to play two games in quick succession and with Reading having to name a makeshift backline, the intelligence of Maguire could be a real weapon. Photo: CameraSport - Alex Dodd