North End go in search of their third win in just six dayt after success against Middlesbrough and Swansea City since Saturday.
The Royals on the other hand have lost and drawn their last two, but are on home soil for the clash.
PNE do not have the best of records against the hosts going into the game, winning just one of their last nine games against Reading, but have a chance to go into the play-offs with a win.
Here’s how we think Ryan Lowe will line up…
5. RWB: Brad Potts
A match winner in midweek, if he can keep getting forwards and contributing to goals he can become an even bigger asset to Ryan Lowe. Photo: CameraSport - Alex Dodd
6. CM: Ryan Ledson
The man brought on when Ben Whiteman had to be replaced is likely to start in his stead on Friday, a quality midfielder all the same. Photo: CameraSport - Alex Dodd
7. CM: Ali McCann
The Northern Irish international is enjoying a long run in the side and results tend to follow when he starts, he puts in an excellent shift. Photo: CameraSport - Alex Dodd
8. CM: Alan Browne
The skipper was described as back to his best by his manager on Tuesday night so is likely to keep his spot in the middle of midfield. Photo: CameraSport - Alex Dodd