Sheffield United are the hosts, the second placed side in the Championship who won promotion on Wednesday. After snatching a last minute draw in their last game, North End will be hoping to go one better this weekend as only a win would realistically give them a chance of making it into the top six.
PNE will be without captain Alan Browne, Robbie Brday, Ched Evans and Emil Riis and Greg Cunningham for the game.
Here’s how we think Ryan Lowe might line his side up...
9. CM: Josh Onomah
Like Danile Johnson, he has the quality that could make a huge difference for PNE this weekend, but whether Josh Onomah is up to the task or not, we will see. Both him and Johnson are struggling with fitness issues so we may not see both start. Photo: CameraSport - Alex Dodd
10. LWB: Alvaro Fernandez
A top quality player that gives North End so much more with him in the side than without, we may be going into the final two games of Alvaro Fernandez in a PNE shirt. Photo: CameraSport - Alex Dodd
11. ST: Tom Cannon
Almost exclusively North End's consistent source of goals, there's a lot of pressure on the 20-year-old to deliver but so far he has and Tom Cannon has to start at Sheffield United. Photo: CameraSport - Alex Dodd
12. Parrott controls the ball
Preston North End's Troy Parrott controls under pressure from Blackburn Rovers' Adam Wharton Photo: CameraSport - Rich Linley