Sheffield United are the hosts, the second placed side in the Championship who won promotion on Wednesday. After snatching a last minute draw in their last game, North End will be hoping to go one better this weekend as only a win would realistically give them a chance of making it into the top six.
PNE will be without captain Alan Browne, Robbie Brday, Ched Evans and Emil Riis and Greg Cunningham for the game.
Here’s how we think Ryan Lowe might line his side up...
5. CB: Andrew Hughes
A consistent presence on the left side of PNE's back three, Andrew Hughes doesn't really have much competition at the moment, with Greg Cunningham out injured and Liam Lindsay out of favour. Photo: CameraSport - Rich Linley
6. RWB: Brad Potts
Another player with little competition, Brad Potts is out on his own with the right wing back position, and has been playing well enough to keep his spot too. Photo: Tim Markland
7. CM: Ben Whiteman
The lynchpin in the middle of North End's midfield, Ben Whiteman was fantastic last time out against Blackburn and will likely start again. Photo: CameraSport - Alex Dodd
8. CM: Daniel Johnson
Provided he's fit enough to start, Daniel Johnson would be an important player for PNE in what is a huge game. He has the experience and the quality they need for a game like Saturday's. Photo: CameraSport - Rich Linley