North End have had happy days in the Midlands in the past, with a 3-1 win in 2017.
Daniel Johnson, the former Aston Villa man, was delighted to score against their arch rivals, as was Jordan Hugill and Tom Barkhuizen as they made it two and three.
Alex Neil’s side actually went behind in the game, to a goal from Maxime Colin, but blew the hosts away with their treble in just 11 second half minutes.
The win helped Preston up to fourth, two points off the top back in September 2017.
5. Daniel Johnson
Preston North End's Daniel Johnson celebrates Photo: CameraSport - Mick Walker
6. Hugill scores
Preston North End's Jordan Hugill scores his side's second goal beating Birmingham City's David Stockdale Photo: CameraSport - Mick Walker
8. Harry Redknapp
Birmingham City's manager Harry Redknapp Photo: CameraSport - Mick Walker