North End have had happy days in the Midlands in the past, with a 3-1 win in 2017.
Daniel Johnson, the former Aston Villa man, was delighted to score against their arch rivals, as was Jordan Hugill and Tom Barkhuizen as they made it two and three.
Alex Neil’s side actually went behind in the game, to a goal from Maxime Colin, but blew the hosts away with their treble in just 11 second half minutes.
The win helped Preston up to fourth, two points off the top back in September 2017.
1. Maguire battles
Preston North End's Sean Maguire battles with Birmingham City's Jacques Maghoma Photo: CameraSport - Mick Walker
2. Hugill celebrates
Preston North End's Jordan Hugill celebrates scoring his sides second goal Photo: CameraSport - Mick Walker
3. Tom Barkhuizen celebrates
Tom Barkhuizen celebrates his goal against Birmingham Photo: Camerasport
4. Johnson celebrates
Preston North End's Daniel Johnson celebrates scoring his sides first goal Photo: CameraSport - Mick Walker