UPDATE: Person suffers 'possible major trauma' after multi-vehicle accident
Two other people were suffered non-serous injuries in the accident happened at around 7.30am this morning at the junction of Chaigley Road and Higher Road.
Higher Road is currently closed while emergency services deal with the incident.
A diversion has been put in place through the Chaigley estate and police are asking people to avoid the area.
Early reports suggest that the accident involved a red Chevrolet Spark, a black Ford Fiesta and a Ford Transit van, say police.
A spokesman for Lancashire Fire and Rescue said: "We were called to reports of a road traffic collision at around 7.35am on Higher Road near to Beacon Fell View Caravan Park.
"Two fire engines from Preston attended the accident which involved two cars and a transit van. We released a man from one of the vehicles using hydraulic cutters and spreaders. The man was taken to hospital via ambulance."
More to follow.