The man, aged in his 20s, had been riding a Harley Davidson motorcycle when he was knocked off his bike at the junction between Eastway and Watling Street Road at 7.08pm.
Officers closed the road for around an hour whilst paramedics treated him at the scene.
No arrests have been made but police are asking those who witnessed the crash to get in touch.
This morning (Tuesday, June 8), a police spokesman said: "We were called to Watling Street Road, Ribbleton, at 7.08pm yesterday (June 7) following reports of a collision involving a Harley Davidson motorcycle and a Mercedes car.
"The male motorcyclist suffered back and arm injuries.
"Anyone with information can call police on 101, quoting log 1306 of June 7, 2021."
A spokesman for North West Ambulance Service added: "We have taken a male patient to hospital suffering serious arm and leg injuries."
Two fire engines from Penwortham and Fulwood also attended the scene and gave first aid to the biker before the arrival of paramedics.
A fire service spokesman said: "Firefighters administered first aid to one casualty before assisting paramedics by conveying the individual onto an ambulance using a scoop stretcher.
"Crews also used a first aid kit, an oxygen therapy kit, a trauma pack and a scoop stretcher at this incident. They were in attendance for forty-five minutes."
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