Police closed the busy junction after the multi-vehicle crash outside Lidl at around 8.25am.
Motorists were initially advised to avoid the area and seek alternative routes, but the road is expected to reopen shortly.
A police spokesman said: "There is currently a road closure in place in New Hall Lane, Preston at the junction with London Road due to a road traffic collision.
"Please avoid the area and take other routes where possible. Thank you for your assistance."
Last night (Sunday, July 11), a section of Deepdale Road was closed by police after a car mounted a kerb and hit a wall before flipping onto its roof outside a shop.
You can read the full report and see pictures from the scene here.
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