Two southbound lanes will remain closed overnight on the M6 between junction 28 near Leyland and Charnock Richard Services while the road is resurfaced.
AA Roadwatch reported severe delays of 45 minutes, with traffic travelling at an average speed of 5pmh.
A Highways England spokesman said: "Severe fuel spillage means resurfacing will be required, closing carriageway overnight. Lane closures to remain in place until then."
Drivers heading from junction 30 are advised to consider using the M61 as an alternative route.