This week demolition work has started at the historic Preston Bus depot in Deepdale Road, ahead of planned redevelopment work.
And as the wheels of progress continue to move forward, many of the familiar and much-loved parts of the city's past have vanished.
From the loss of Wesley Street Mill to Preston's indoor market and car park, here are some of the building the city has said goodbye to over the years.
What are your memories of these landmarks and buildings in and around Preston?
1. Sharoe Green Hospital
Sharoe Green Hospital in Fulwood which opened in 1869 was originally built to house 1,500 people. The facility finally closed in 2004, and following an arson attack was demolished in 2006.
2. Wesley Street Mill
This former home of the Bamber Bridge Spinning and Weaving Company closed as a working mill in 1959. Demolition began in 2013. The site was eventually redeveloped into housing.
3. Whittingham Hospital
Whittingham Hospital originally opened in 1873 as the fourth Lancashire County Asylum to accommodate 1,000 patients. The hospital eventually closed in 1995 and was demolished in 2014.
4. Moor Lane flats
Built in the 1960s, Preston's Moor Lane flats were toppled in 2001 after abseiling surveyors found the 40 year old buildings were unsafe. 300 people were evacuated from the surrounding area during the controlled explosion.