Preston land FA Cup clash with Sheffield United
It was the last tie out of the hat in the draw made at Brighton's Amex Stadium on Monday night.
The sides met at the same stage of the FA Cup three years ago.
They drew 1-1 at Deepdale before North End won 3-1 in the replay in South Yorkshire, Paul Gallagher scoring twice and Paul Huntington finding the net - it set up a fifth round tie with Manchester United.
PNE and the the Blades met in the league last month, Jordan Hugill's goal giving Preston a 1-0 win.