Goals from Neil Mellor and two from Chris Brown saw the Lilywhites to a victory on the seaside, with Adam Hammill socring for the home side.
Blackpool took the lead inside 10 minutes but a second half fight back for North End saw them to the three points.
PNE Starting XI: Lonergan, Jones, St. Ledger, Wayne Brown, Davidson, Sedgwick, McKenna, Chaplow, Wallace, Chris Brown, Mellor (Elliott 89).Subs Not Used: Mawene, Nicholson, Parkin, Neal.
Blackpool Starting XI: Rachubka, Barker, Evatt, Edwards, Camara, Taylor-Fletcher (Hendrie 74), Southern (McPhee 74), Jorgensen, Hammill, Burgess, Gow (Kabba 60).Subs Not Used: Broomes, Fox.
5. Mellor makes it 2-1
Neil Mellor heads PNE into the lead at Bloomfield Road. Photo: Kevin McGuinness
6. Another angle of Mellor's header
Neil Mellor's header beats Paul Rachubka for Preston's second goal. Photo: Bill Johnson
7. Neil Mellor celebrates his goal
Neil Mellor celebrates his goal to make it 2-1 at Bloomfield Road. Photo: Kevin McGuinness
8. It's all over now
Chris Brown makes it 3-1 to secure the win for PNE. Photo: Bill Johnson