Casting his full set of predictions for Sky Sports ahead of the game, former footballer David Prutton backed a 1-0 away win for the Lions.
Elsewhere, Prutton tipped Huddersfield Town to beat Birmingham City, Middlesbrough to beat Coventry City, and stalemates in Swansea City vs Stoke, and Derby County vs Cardiff City.
The last time the Lilywhites faced Millwall, back in February, Shaun Hutchinson's second-half strike saw the Lions claim a narrow 1-0 win at Deepdale.
Over the course of their last ten matches, Preston have won on three occasions to Millwall's four, with the remaining three encounters finishing as draws.
As things stand, the Lilywhites are 12th in the table with ten points from seven matches, while the Lions are seventh with 12 points.