The Lilywhites head into the game off the back of a confident 3-0 Carabao Cup win over Mansfield, and will look to take that positive momentum into their clash against the Royals, and put the opening day 4-1 hammering by Hull City far behind them.
When the two sides last faced each other, back in January, the two sides played out a goalless draw. However, their last meeting at the Madjeski stadium saw Preston storm to an impressive 3-0 win, with goals from Scott Sinclair, Emil Riis and Brad Potts securing three points for their side.
Speaking after his side's first-round cup win over Mansfield, Preston boss Frankie McAvoy said: “I thought Scotty (Sinclair) was excellent and it was great to see him score twice.
“In training on Monday we had done a lot of work to get Scotty and Sean Maguire linking up in and around the penalty box. Before he scored the first goal, Scotty had a chance from Sean playing him in.
“His goal came from them linking up again, so that was a big plus for us. They hadn’t been available for Hull because they were isolating, so this was a good chance for them to play.
“I put Emil (Riis) on knowing we needed a second goal and I knew he would give us that spark we needed.”
We’ve gathered the best of today’s transfer speculation below…
5. Forest youngster keen to break into side
Nottingham Forest midfielder Tyrese Fornah has revealed he's looking to give his manager Chris Hughton a "selection headache" after starring in his side's Carabao Cup win over Bradford City. The 21-year-old was making his first start for the club, after spending last season on loan with Plymouth (BBC Sport) Photo: Lewis Storey
6. Blackpool's Gabriel hopes fade
Blackpool's hopes of bringing Jordan Gabriel back to the club look to have taken a blow, with reports suggesting Nottingham Forest will only agree to part company with their player if a "big cash offer" is made. He impressed on loan with the Tangerines last season. (The Sun) Photo: Charlotte Tattersall
7. Barnsley join Brown battle
Barnsley and Blackburn Rovers have both been credited with an interest in Cardiff City defender Ciaron Brown. Middlesbrough have recently seen a bid for the player knocked back, with his club eager to keep him there in the long-term. (Football League World) Photo: Justin Setterfield
8. Blues handed transfer boost
Birmingham City have been handed a boost in their hopes of re-signing former star defender Scott Dann. The veteran centre-back, who won the League Cup with the Blues back in 2011, has just been released by Crystal Palace. (The 72) Photo: Dan Mullan