PNE announced the news on Twitter on Friday morning.
The game will take place on Wednesday, October 27, at 7.45pm in front of the Sky Sports cameras.
Frankie McAvoy’s side reached the last 16 thanks to a 4-1 win over Cheltenham Town on Tuesday, with Liverpool beating Norwich City 3-0.
It is sure to be a sell-out crowd at Deepdale and will be the first meeting between the clubs since they played in the FA Cup at Deepdale in January 2009, Liverpool winning 2-0.