Alan Browne, Andrew Hughes and Tom Barkhuizen returned to the side in place of Ali McCann, Greg Cunningham and Sean Maguire.
Cunningham dropped to the bench as Hughes returned from a toe injury, with McCann (ankle) and Maguire (hamstring) out injured.
It was Barkhuizen's first slice of senior action since the opening game of the season.
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The front man had been suffering from the after-affects of Covid but has proved his fitness in two reserve games.
Patrick Bauer recovered from a dead leg which forced his substitution at half-time in the last game at QPR before the international break.
PNE: Iversen, Storey, Bauer, Hughes, Van den Berg, Ledson, Browne, Johnson, Earl, Barkhuizen, Riis. Subs: Rudd, Cunningham, Whiteman, Lindsay, Sinclair, Potts, Murphy.
Derby: Allsopp, Ebosele, Jagielka, Davies, Buchanan, Shinnie, Bird, Knight, Morrison, Lawrence, Baldock. Subs: Roos, Jozwiak, Kazim-Richards, Stearmann, Sibley, Watson, Williams,
Referee: Joshua Smith (Stamford)
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