PNE got a point in PR1 last time out, coming from behind with 10 men to get a point against play-off side Luton Town.
It was their first point in their last five games, having lost them all, but will be needing to go one better against the Latics.
Shaun Maloney’s men are bottom of the league but are unbeaten in his four games in charge so far, and are the only side in the Championship with a worse home record than the Lilywhites.
PNE, meanwhile, are searching for their first home win since November 1.
Ryan Lowe could make some changes this weekend, with a couple of injuries and suspensions forcing him away from his usual choices, and performances must improve too.
9. CM: Daniel Johnson
Daniel Johnson was brought on towards the end of the Hull game and deserves a chance to show he can nail down a starting spot, given that Ben Woodburn got that chance at the weekend. Photo: CameraSport - Rich Linley
10. LWB: Alvaro Fernandez
Alvaro Fernandez has been one of the brightest players for North End over the last few games so should start against Wigan. Photo: CameraSport - Alex Dodd
11. ST: Tom Cannon
Tom Cannon has been the best performer of the three loan strikers in recent weeks and only lacks a goal - which he could have had should plans been followed for the penalty against Luton. Photo: CameraSport - Alex Dodd
12. ST: Troy Parrott
Troy Parrott had a great impact at Hull and despite Lowe's want to protect him, he needs him on the pitch at the moment. Ched Evans returns for the next game to give the Irishman a rest. Photo: CameraSport - Alex Dodd