Brown was one of four summer signings made to date by the Lilywhites, with a loan deal for Daniel Iversen and the addition of a striker still to do.
The injury to Brown, one he suffered in training, could now see North End look to bring in another player who has the versatility to play a number of attacking roles.
With pre-season in full flow, the transfer market in the Championship isn't hugely busy at the moment, with talk of deals rather than deals actually getting done being the order of the day.
The summer transfer window has plenty of time to run, with it closing on August 31.
Here is a round-up of the latest Championship talk.
5. Baggies attacker attracting interest
West Bromwich Albion's Matheus Pereira is being tracked by West Ham. (Daily Express) Photo: Press Association
6. Davies turns out for Reds amid speculation over his future
Former PNE defender Ben Davies played in Liverpool's friendly against Wacker Innsbruck in Austria yesterday, Sheffield United, Celtic and Bournemouth are said to be interested. (Various) Photo: Press Association
7. Bournemouth sell keeper to Toffees
Bournemouth have sold goalkeeper Asmir Begovic to Everton for an undisclosed fee. (Various) Photo: Mick Walker
8. Brown injury blow for PNE
Preston could be forced into the transfer market to replace Izzy Brown after a ruptured Achilles tendon ruled the attacker out for several months. (Lancashire Post) Photo: Press Association