After triumphs over Southampton and Swansea City in the past week, a trip to the capital is on the cards for the Lilywhites, who are looking to head into the international break on a high.
Paul Heckingbottom’s men are on a three-game winning run, with the midweek victory over the Swans moving them up to fourth in the table.
They face a Millwall side no under the leadership of former PNE boss Alex Neil, with the Lions sitting just a place below North End in fifth.
We’ve taken a look at the early team and injury news from both camps ahead of this lunchtime’s Championship contest.
5. Josh Coburn - Out
The striker is set to be out of action for months after picking up a quad injury at the start of October. | Getty Images
6. Andrija Vukcevic - Out
Vukcevic remains absent as he begins his recovery from a hamstring injury suffered against Sheffield United more than a fortnight ago. The midfielder is expected to be out for a couple of months. | CameraSport - Alex Dodd
7. Ryan Leonard - Out
The right-back is out with a calf injury and is set to miss a couple of months worth of action, according to Neil. | Getty Images
8. Will Keane - Out
Keane has missed all 14 of PNE’s Championship matches so far this term due to a calf injury picked up in pre-season. The forward is, though, back on the grass and eyeing a return after the international break. | CameraSport - Dave Howarth