The Lilywhites have a chance to go within a point of the play-off places with a win, and could also have a fully fit squad available.
Ryan Lowe has said he could leave out three first team players from the matchday squad entirely, with Ben Whiteman, Ched Evans and Brad Potts all looking likely to be back fit for the weekend.
Here’s how we think North End could line up...
5. CB - Andrew Hughes
He gives balance to North End's backline and was a part of their solid defensive start to the season. It may be time to get back to that. Photo: CameraSport - Mick Walker
6. RWB - Alan Browne
With Brad Potts only just coming back from injury, the skipper looks likeliest to continue on the right side. Photo: CameraSport - Rich Linley
7. CM - Ben Whiteman
So far, if Ben Whiteman has been fit, in every single game under Ryan Lowe, he has started. Lowe also has no reason to stay loyal to any players from last week either. Photo: CameraSport - Dave Howarth
8. CM - Ryan Ledson
Due to other players' form, Ryan Ledson could get the start against Birmingham, even if it potentially means it's a more defensive approach. Lowe wants to get back to basics and keep the ball out of the net and two holding midfielders could help in that regard. Photo: CameraSport - Rich Linley