Wales also get their bid for European glory underway this weekend, coming up against Switzerland on Saturday.
And after an extended wait due to the Coronavirus pandemic, and a positive weather forecast for most of the country, England supporters are anticipated to bring in the new tournament in style, with no expense spared.
A study from Voucher Codes predicts that supporters will spend around £397 million this weekend, with some £63 million spent in pubs and other screening venues alone.
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Around 5.1 million punters are expected to descend on pubs across the country, spending an average of £12.35 each.
The vast majority of money will be spent by fans choosing to watch the game from the comfort of their own home, however.
In total, supporters are expected to splash £334 million, with a massive £189 million spent on food alone.
A further £108 million will be spent on drink, while many viewers are forecast to go the extra mile by buying a new TV for the occasion.
Searches for TV package deals have increased 506% in the buildup to the tournament, and sales could total around £20 million.
The rest of the £334 million will be made up by fans purchasing other merchandise, such as replica shirts.