A Ford Focus collided with a telegraph post in Talbot Drive, Euxton, at around 8.25am on Tuesday (April 19).
The driver, a woman in her 60s, was taken to hospital for treatment but sadly died a short time later.
Police confirmed her death was not being treated as suspicious and a file will be passed to the coroner.
Anyone with information can contact the police by calling 101, quoting log number 0270 of April 19.