Two engines attended the scene at the roundabout junction with Blackpool Road at 2.41pm.
Lancashire Police also attended the crash, which it described as "damage-only", with no injuries reported.
The road was closed for around 20 minutes, leading to some delays, before it was reopened at around 3pm.
A fire service spokesman said: "At 2.41pm, two fire engines from Preston attended a road traffic collision on New Hall Lane, Preston.
"The incident involved three vehicles. Firefighters worked to make the scene safe and were in attendance for approximately twenty minutes."