Fire crews tore the roof of an overturned car to free the man who was trapped inside after a crash with an on-call ambulance in Plungington Road at around 9.30am.
The casualty was rushed to Royal Preston Hospital with major trauma injuries, said the ambulance service. The two ambulance crew members were not injured.
Pictures from the scene show the wreck of the silver car which had rolled onto its side after the collision.
You can read our full report on the incident with statements from police and North West Ambulance Service here.
5. Preston ambulance crash in Plungington Road
A man has suffered major trauma injuries after his car was struck by an ambulance in Preston this morning (Friday, June 17) Photo: Kelvin Stuttard
6. Preston ambulance crash in Plungington Road
The injured driver was then rushed to the Major Trauma Ward at Royal Preston Hospital with life-threatening injuries Photo: Kelvin Stuttard
7. Preston ambulance crash in Plungington Road
Police are at the scene and Plungington Road remains cordoned at the junctions with Adelphi Street and Aqueduct for investigation Photo: Kelvin Stuttard
8. Preston ambulance crash in Plungington Road
Fire crews freed the casualty who was trapped inside the overturned car after a crash with an on-call ambulance in Plungington Road at around 9.30am Photo: Kelvin Stuttard