School Lane was closed whilst ambulance crews attended the scene near the junction with Haig Avenue at around 9.30am.
Two ambulances attended and two female patients have been assessed and treated at the scene.
North West Ambulance Service said the pair suffered minor injury and have not been taken to hospital.
The age of the patients has not been provided at this stage.
School Lane remained closed as of 10.30am, with officers diverting traffic away from the scene.
A police spokesman said: "Please be aware there is a road closure currently in place in School Lane, Leyland (at the junction of Haig Avenue).
"This is whilst police attend the scene of a road traffic collision.
"We will update you when the road is open again. In the meantime please use alternative routes."
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