The crash happened in Blackpool Road (A586), St-Michael's-on-Wyre at 6.15pm yesterday (Monday, March 30).
Emergency services rushed to the scene where a car was found upside down and ablaze in a field.
It is not known how many occupants where in the car, but one man has been taken to hospital after suffering serious head injuries.
M6 reopens after vehicle transporting sheep overturns following crash between Preston and Lancaster
The Old Vicarage Care Home: special measures status for Lancashire care home where resident was left lying on floor after falling out of bed
Lytham St Annes care home boss appears in court after death of residents
Preston Brick Veil Mosque inquiry closes as debate rages over whether the place of worship should be permitted
M65 motorway crews strimming verges until 4am keep residents awake at night
He is currently in a critical condition at Royal Preston Hospital.
Police said the driver has since been arrested on suspicion of drug driving and dangerous driving.
Fire crews from Garstang and Blackpool remained at the scene for around an hour and used 60 litres of foam to extinguish the blaze.
Prior to the arrival of paramedics, police officers used trauma skills to treat the driver, whilst firefighters also administered first-aid to a casualty.
A fire service spokesman said: "At 6.16pm, two fire engines from Garstang and Blackpool attended a road traffic collision in Blackpool Road, St-Michaels-on-Wyre.
"On arrival crews found one vehicle which had left the roadway and was found upside down in a field and on fire.
"Crews used two breathing apparatus, two hose reels, 60 litres of foam and a thermal imaging camera to extinguish the fire.
"Firefighters administered first-aid to one casualty. Firefighters were at the scene for approximately one hour."
"A man has suffered serious head injuries and has been taken to Royal Preston Hospital."
Police were forced to close the A586 between St Michael's and Greater Eccleston for four hours before the road reopened at 10.30pm.
Following the crash, Lancashire Road Police urged people not to drive unless absolutely essential.
"This is one of the reasons we want to limit your road journeys at the moment, so we don’t burden the NHS," tweeted an officer.
"Colleagues used trauma skills at the scene to treat the driver, placing themselves at risk. The journey was clearly not essential."