All traffic was temporarily held due to recovery work after a car struck the central reservation.
All lanes are now open.
It is not know whether anyone has been injured at this stage.
Lancashire Police and North West Ambulance Service have been approached for details.
All lanes are back open and traffic has returned to normal on the M65 after a crash this morning.
Lane 2 was closed for emergency barrier repairs after the crash on the westbound carriageway between junctions 5 (Guide / Shadsworth) and 4 (Darwen / Blackburn South).