One lane was closed on the M60 anticlockwise between junctions 11 (Peel Green Interchange) and 10 (Redclyffe Circle) at around 3.45pm
The crash reportedly involved a lorry and a car, according to the AA.
Traffic officers, police and paramedics were called to the scene and heavy traffic was building in the area.
The collision was cleared and all lanes reopened at around 4.30pm.
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