Highways have shut the northbound entry slip road at junction 23 in Haydock (A580 East Lancashire Road) whilst the lorry is recovered.
The lorry also caused some spillage on the carriageway and this will need to be treated before the slip road can reopen.
Highways say traffic is coping well, despite it happening in the roadworks area where a 50mph speed limit is in force.
Lane one (Of three) was closed after the lorry broke down, but re-opened by 6.35am, however the entry slip road remains closed.