Grane Road was closed from Elton Road, near the Grey Mare, all the way through to the Holden Arms at approximately 6.50am on Thursday (February 24).
Police said this was "due to severe weather conditions and a road traffic collision," and the closure would be in place "for some time".
"Please can drivers take this into consideration when driving," a spokesman for Lancashire Police said.
In an update posted at 10.40am, police confirmed the road had reopened.
Officers said the collision involved two vehicles but it was "damage only.".
It is thanks to our loyal readers that we can continue to provide the trusted news, analysis and insight that matters to you.
For unlimited access to our unrivalled local reporting, you can take out a subscription HERE and help support the work of our dedicated team of reporters.