Reports of the collapse in Dunkirk Lane, close to the junction of Paradise Lane and Moss Side shops, were first received at around 2pm.
Moss Side Councillor Michael Green said: “I imagine it’s probably something to do with the sewage pipes underneath. We had something similar in Slater Lane a while ago.
“County Highways are aware of the situation and the area has been cordoned off, but it might take a while before it’s resolved.
“I imagine traffic will build up around there, so if people can avoid the area, it’s probably wise to do so.”