The diversion, which will affect the route on the west side of Preston, will be in place from January 6, 2020 while construction continues on the new Preston Western Distributor road.
People attempting to travel along the Guild Wheel section between Savick Brook and the bridge over Blackpool Road will be redirected towards the side of Riversway, and then up towards Savick Brook.
Construction of the new £200m road which will link Preston and southern Fylde to the M55 is scheduled to finish early in 2023.