A man in his 70 has been flown to hospital for emergency treatment following a gas explosion at his home in Bleasdale Street East at around 10.50am.
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"I heard a big bang and the dog panicked," Mary Priestley said. "Then I looked out the window and there were fire engines, the police, the lot. I couldn't believe what was happening."
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Another shocked resident who felt the blast rock their home said "the ground felt like an earthquake when it happened".
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Firefighters from Preston, Bamber Bridge, Urban Search and Rescue and an aerial appliance from Preston attended the scene.
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Initial reports from the emergency services suggested gas was the cause of the explosion.