Police closed off part of Northgate at its junction with Whitegate on Monday afternoon after reports of a bomb being found.
They say the cordon is expected to remain in place today, Tuesday, while bomb disposal experts work at the scene.
Lancashire Police said: "We were called at around 3.15pm (Monday) to reports an unexploded shell had been found at the White Lund Industrial Estate in Morecambe.
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"The shell was uncovered by contractors doing work in the area.
"EOD [Explosive Ordinance Disposal] are en route to the area and a cordon is now in place. We are asking motorists to avoid the area and find alternative routes where possible.
"We will update when the cordon has been lifted."