Husband and wife duo Jim and Jan Doran will attend the 8pm concert at Broadfield Walk in support of the British Heart Foundation.
No stranger to tragedy, the retired couple first considered hosting the concert following the deaths of two of their nephews just before the Covid pandemic.
Both men, one from each side of the family, were just 42 year's old. Philip Brough, died of a rare cancer of the heart, while Antony Doran, died of a heart attack within a week of winning a major amateur golf tournament.
However, the pandemic then took hold, putting all plans on ice.
Sadly, during this time in May Jan's mother Patricia O'Farrell, 94, passed away with dementia, caused by blood circulation problems, meaning that both sets of parents had heart-related conditions as the primary cause of death.
Explaining how this all came to fruition, Jim, 74, said: "Jan is the lead support for the band.
"Both my parents James and Ignes died from a heart attack as did Jan's father Les Brough."
As restrictions were easing and arrangements were being finalised, tragedy struck again with a friend of Jan's, and a supporter of Leyland Band, Jim Washington, of Longton, passing from a stroke, followed very shortly by the death, from a heart attack, of the band's President and former conductor, Mr. Richard Evans, also from Longton.
Playing pieces in memory of their cousins and their grandparents will be band members Colin and Chris Doran, who will be joined on the night by their uncle Paul Brough, formerly a member of the local Lostock Hall band and now resident in Congleton.
Members of Antony Doran's family should also be in attendance on the evening having travelled up from Derby to support the charity.
Jim and Jan's sons Christopher, 39, and Colin 42, who play in the band will also perform.
Tickets for the concert are priced at £10 and are on sale at Electra, Hough Lane or by contacting Jan on: 01772 813895. You can also pay at the door.
Jim added: "Every ticket sold will go towards the British Heart Foundation."