Police believe Connor McManus, who has been reported missing from his home address in Manchester, could be in the Chorley area.
The 17-year-old is described as a white male, 6ft tall, of slim build with short brown hair.
He was last seen wearing black tracksuit bottoms and a black jacket.
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Connor is also believed to have links to Preston.
"We are now concerned for Connor's welfare and are appealing for your help to find him," a spokesman for Lancashire Police said.
If you have seen Connor or have any information about his whereabouts, call 101 quoting log number 04/144974/21.
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