A police spokesman said cars are currently being diverted off the exit slip road at junction 10 (Burnley/Padiham/A671).
Emergency services are at the scene of the incident.
The spokesman added: "We have had to close the M65 between junctions 10 and 12 eastbound due to a road traffic collision. Cars are currently being diverted off the exit slip road at junction 10. Please avoid the area where possible, to assist emergency vehicles in attendance.
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"We will provide an update once the motorway is open."