The incident involved a “chemical leak”, according to Lancashire Fire and Rescue Service.
“Firefighters are working with United Utilities and other partners to make the scene safe,” a spokesman added.
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“No injuries have been reported.”
The incident reportedly involved a tanker that had leaked, according to eyewitness reports.
A spokesperson for United Utilities said: “We are attending in an advisory capacity to ensure there is no adverse effect on the drainage network.
“This has not affected drinking water supplies in the area.”
A 50m safety cordon was put in place near Evans Vanodine International as firefighters washed down the tanker and the surrounding area.
A number of police vehicles also attended to block off a section of Brierley Road.
Firefighters remained in attendance for approximately five and a half hours.